Population pharmacokinetics of intramuscular recombinant Erwinia chrysanthemi asparaginase (JZP458) in patients with acute lymphoblastic leukemia

• Main Authors: Tong Lin (Author), Tajhia Whigham (Author), Indrasiri Fernando (Author), Mi Rim Choi (Author), Qi Wang (Author), Jeffrey A. Silverman (Author)
• Formato: Libro
• Publicado: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract JZP458 is a recombinant Erwinia chrysanthemi asparaginase for patients with acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL) who have developed hypersensitivity to Escherichia coli-derived asparaginases. A population pharmacokinetic (PopPK) model was developed for intramuscul...