Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens.

Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens.

The spleen is one of the main affected organs in canine visceral leishmaniasis (CVL). Disorganization of the splenic white pulp (SWP) has been associated with immunosuppression and disease progression. This study aims to assess structural and cellular changes in the splenic extracellular matrix of d...

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Main Authors: Aurea Virginia Andrade da Silva (Author), Fabiano Borges Figueiredo (Author), Rodrigo Caldas Menezes (Author), Arthur Augusto Mendes-Junior (Author), Luisa Helena Monteiro de Miranda (Author), Elisa Cupolillo (Author), Renato Porrozzi (Author), Fernanda Nazaré Morgado (Author)
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Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
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