In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

• Main Authors: Miaoran Ning (Author), Liang Li (Author), Jian Li (Author), Zaiquan Li (Author), Runtao Li (Author), Tianyan Zhou (Author), Wei Lu (Author)
• Format: Book
• Published: Elsevier, 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TM208 and TM209, dithiocarbamate derivatives with potential anti-cancer effects, were evaluated in reversible and time-dependent cytochrome P450 (CYP) 3A inhibition assays in rat liver microsomes using testosterone as probe substrate. Both compounds were found to be weak reversible inhibitors and mo...