Pulmonary Pharmacokinetic and Pharmacodynamic Evaluation of Ampicillin/Sulbactam Regimens for Pneumonia Caused by Various Bacteria, including <i>Acinetobacter baumannii</i>

• Main Authors: Tetsushu Onita (Author), Kazuro Ikawa (Author), Noriyuki Ishihara (Author), Hiroki Tamaki (Author), Takahisa Yano (Author), Kohji Naora (Author), Norifumi Morikawa (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2023-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

This study aimed to assess the dosing regimens of ampicillin/sulbactam for pneumonia based on pulmonary pharmacokinetic (PK)/pharmacodynamic (PD) target attainment. Using the literature data, we developed pulmonary PK models and estimated the probabilities of attaining PK/PD targets in lung tissue....