Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

• Main Authors: Xiaoqing Wang (Author), Ju Zhu (Author), Lingling Li (Author), Qilin Zhao (Author), Yutang Huang (Author), Chunjie Wen (Author), Dan Chen (Author), Lanxiang Wu (Author)
• Formato: Livro
• Publicado em: BMC, 2024-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens. Methods Histopathological examination, immunohistochemistry and whole-exome sequen...