Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG

Loss of function (LOF) mutations of voltage sensitive K+ channel proteins hERG (Kv11.1) and KCNQ1 (Kv7.1) account for the majority of instances of congenital Long QT Syndrome (cLQTS) with the dominant molecular phenotype being a mistrafficking one resulting from protein misfolding. We explored the u...

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Main Authors: Yihong Zhang (Author), Amy L. Grimwood (Author), Jules C. Hancox (Author), Stephen C. Harmer (Author), Christopher E. Dempsey (Author)
Format: Book
Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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