Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast

• Main Authors: Barry P. Young (Author), Kathryn L. Post (Author), Jesse T. Chao (Author), Fabian Meili (Author), Kurt Haas (Author), Christopher Loewen (Author)
• Format: Book
• Published: The Company of Biologists, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Advances in sequencing technology have led to an explosion in the number of known genetic variants of human genes. A major challenge is to now determine which of these variants contribute to diseases as a result of their effect on gene function. Here, we describe a generic approach using the yeast S...