Preparation of Nanoparticles Loaded with Membrane-Impermeable Peptide AC3-I and Its Protective Effect on Myocardial Ischemia and Reperfusion

• Main Authors: Yi Liu (Author), Yingyi Niu (Author), Wenjie Zhang (Author), Kaikai Wang (Author), Tianqing Liu (Author), Weizhong Zhu (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: It is well known that inhibition of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) provides cardiac protection in cases of myocardial ischemia-reperfusion injury. However, there are currently no cytoplasm-impermeable drugs that target CaMKII. The aim of this stu...