The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats

• Autori principali: Francisco V. Souza-Neto (Autore), Sara Jiménez-González (Autore), Beatriz Delgado-Valero (Autore), Raquel Jurado-López (Autore), Marie Genty (Autore), Ana Romero-Miranda (Autore), Cristina Rodríguez (Autore), María Luisa Nieto (Autore), Ernesto Martínez-Martínez (Autore), Victoria Cachofeiro (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We have evaluated the role of mitochondrial oxidative stress and its association with endoplasmic reticulum (ER) stress activation in the progression of obesity-related cardiovascular fibrosis. MitoQ (200 µM) was orally administered for 7 weeks to male Wistar rats that were fed a high-fat diet (HFD,...