Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer

• Main Authors: Yang-Yang Wang (Author), Liang Li (Author), Xiu-Jun Liu (Author), Qing-Fang Miao (Author), Yi Li (Author), Meng-Ran Zhang (Author), Yong-Su Zhen (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Folate receptor (FR) overexpression occurs in a variety of cancers, including pancreatic cancer. In addition, enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer. Furthermore, the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer. In this study...