The Pharmacological and Structural Basis of the AahII-NaV1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

• Main Authors: Riadh Hmaidi (Author), Ayoub Ksouri (Author), Rahma Benabderrazek (Author), Viviane Antonietti (Author), Pascal Sonnet (Author), Mathieu Gautier (Author), Balkiss Bouhaouala-Zahar (Author), Halima Ouadid-Ahidouch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (NaV) channels leading to several neuro- and cardiotoxic effects in mammals. The toxin AahII is the most active α-toxin from the North African scorpion Androctonus australis Hector that slows the fa...