The Mineralocorticoid Receptor on Smooth Muscle Cells Promotes Tacrolimus-Induced Renal Injury in Mice

• Päätekijät: Stefanny M. Figueroa (Tekijä), Jean-Philippe Bertocchio (Tekijä), Toshifumi Nakamura (Tekijä), Soumaya El-Moghrabi (Tekijä), Frédéric Jaisser (Tekijä), Cristián A. Amador (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2023-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Tacrolimus (Tac) is a calcineurin inhibitor commonly used as an immunosuppressor after solid organ transplantation. However, Tac may induce hypertension, nephrotoxicity, and an increase in aldosterone levels. The activation of the mineralocorticoid receptor (MR) is related to the proinflammatory sta...