Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

• Main Authors: Giulia Rotondi (Author), Paolo Guglielmi (Author), Simone Carradori (Author), Daniela Secci (Author), Celeste De Monte (Author), Barbara De Filippis (Author), Cristina Maccallini (Author), Rosa Amoroso (Author), Roberto Cirilli (Author), Atilla Akdemir (Author), Andrea Angeli (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional...