Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica.

• Main Authors: Mark W Robinson (Author), Ileana Corvo (Author), Peter M Jones (Author), Anthony M George (Author), Matthew P Padula (Author), Joyce To (Author), Martin Cancela (Author), Gabriel Rinaldi (Author), Jose F Tort (Author), Leda Roche (Author), John P Dalton (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cath...