Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

• Asıl Yazarlar: Saadane Aicha (Yazar), Eastman Jean (Yazar), Berger Melvin (Yazar), Bonfield Tracey L (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2011-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Excessive secretion of IL-8 characterizes cystic fibrosis (CF). This has been attributed to excessive activation of epithelial cell I-κB Kinase and/or NFκB. Maximum IL-8 production requires 3 cooperative mechanisms: 1) release of the...