Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

• Auteurs principaux: Saadane Aicha (Auteur), Eastman Jean (Auteur), Berger Melvin (Auteur), Bonfield Tracey L (Auteur)
• Format: Livre
• Publié: BMC, 2011-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Excessive secretion of IL-8 characterizes cystic fibrosis (CF). This has been attributed to excessive activation of epithelial cell I-κB Kinase and/or NFκB. Maximum IL-8 production requires 3 cooperative mechanisms: 1) release of the...