Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

Abstract Background Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intestinal P-glycoprotein (P-gp) expression and decreased absorption of its...

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Main Authors: Toshiaki Tsuchitani (Author), Takeshi Akiyoshi (Author), Ayuko Imaoka (Author), Hisakazu Ohtani (Author)
Format: Book
Published: BMC, 2021-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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