From Batch to the Semi-Continuous Flow Hydrogenation of <i>p</i>NB, <i>p</i>NZ-Protected Meropenem

• Main Authors: Marziale Comito (Author), Riccardo Monguzzi (Author), Silvia Tagliapietra (Author), Angelo Maspero (Author), Giovanni Palmisano (Author), Giancarlo Cravotto (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Meropenem is currently the most common carbapenem in clinical applications. Industrially, the final synthetic step is characterized by a heterogeneous catalytic hydrogenation in batch mode with hydrogen and Pd/C. The required high-quality standard is very difficult to meet and specific conditions ar...