The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart

• Main Authors: Yoshioki Satoh (Author), Atsushi Sugiyama (Author), Akira Takahara (Author), Kentaro Ando (Author), Kai Wang (Author), Sachiko Honsho (Author), Keitaro Hashimoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (≤ 3mg/kg, i.v.) did not induce cardiohemodynamic collapse...