In-silico studies to recognize repurposing therapeutics toward arginase-I inhibitors as a potential onco-immunomodulators

• Main Authors: Magdi E. A. Zaki (Author), Sami A. Al-Hussain (Author), Aamal A. Al-Mutairi (Author), Abdul Samad (Author), Arabinda Ghosh (Author), Somdatta Chaudhari (Author), Pravin N. Khatale (Author), Prashant Ajmire (Author), Rahul D. Jawarkar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rudolf Virchow was the first person to point out the important link between immune function and cancer. He did this by noticing that leukocytes were often found in tumors. Overexpression of arginase 1 (ARG1) and inducible nitric oxide synthase (iNOS) in myeloid-derived suppressor cells (MDSCs) and t...