Estimation of Mycophenolic Acid Exposure in Heart Transplant Recipients by Population Pharmacokinetic and Limited Sampling Strategies

• Main Authors: Xipei Wang (Author), Yijin Wu (Author), Jinsong Huang (Author), Songgui Shan (Author), Mingjie Mai (Author), Jiade Zhu (Author), Min Yang (Author), Dewei Shang (Author), Zheng Wu (Author), Jinhua Lan (Author), Shilong Zhong (Author), Min Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The aim of this study is i) to establish a strategy to estimate the area under the curve of the dosing interval (AUC0-12h) of mycophenolic acid (MPA) in the heart transplant recipients and ii) to find the covariates that significantly affect the pharmacokinetics of MPA exposure.Methods: Thi...