The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

• Main Authors: Jeppe Egedal Kirchhoff (Author), Mark Alexander Skarsfeldt (Author), Kalai Mangai Muthukumarasamy (Author), Rafel Simó-Vicens (Author), Sofia Hammami Bomholtz (Author), Lea Abildgaard (Author), Thomas Jespersen (Author), Ulrik S. Sørensen (Author), Morten Grunnet (Author), Bo Hjorth Bentzen (Author), Jonas Goldin Diness (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IKCa, is considered a promising new target for treat...