Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of TH1 and TH17 cytokines in protection and pathology.

• 主要な著者: Kristin Moderzynski (著者), Liza Heine (著者), Jessica Rauch (著者), Stefanie Papp (著者), Svenja Kuehl (著者), Ulricke Richardt (著者), Bernhard Fleischer (著者), Anke Osterloh (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4+ TH1 and cytotoxic CD8...