To Be Drug or Prodrug: Structure-Property Exploratory Approach Regarding Oral Bioavailability

• Egile Nagusiak: Mariana Celestina Frojuello Costa Bernstorff Damião (Egilea), Kerly Fernanda Mesquita Pasqualoto (Egilea), Michelle Carneiro Polli (Egilea), Roberto Parise Filho (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Purpose. Prodrug design is a strategy that can be used to adjust physicochemical properties of drugs in order to overcome pharmacokinetic problems, such as poor oral bioavailability. However, Lipinski´s and Veber´s rules predict whether compounds will have absorption problems even before the design...