Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

• Main Authors: Kiran George (Author), Diego Lopez-Mateos (Author), Tarek Mohamed Abd El-Aziz (Author), Yucheng Xiao (Author), Jake Kline (Author), Hong Bao (Author), Syed Raza (Author), James D. Stockand (Author), Theodore R. Cummins (Author), Luca Fornelli (Author), Matthew P. Rowe (Author), Vladimir Yarov-Yarovoy (Author), Ashlee H. Rowe (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanisms that couple activation to inactivation. Interact...