Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

• Main Authors: Karelle Ménochet (Author), Hongbin Yu (Author), Bonnie Wang (Author), Jay Tibbitts (Author), Cheng-Pang Hsu (Author), Amrita V. Kamath (Author), Wolfgang F. Richter (Author), Andreas Baumann (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies (mAbs) deliver great benefits to patients with chronic and/or severe diseases thanks to their strong specificity to the therapeutic target. As a result of this specificity, non-human primates (NHP) are often the only preclinical species in which therapeutic antibodies cross-rea...