Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

• Main Authors: Bozhao Li (Author), Jingyan Wei (Author), Chunzhi Di (Author), Zefang Lu (Author), Feilong Qi (Author), Yinlong Zhang (Author), Wei Sun Leong (Author), Lele Li (Author), Guangjun Nie (Author), Suping Li (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer therapy. Among vascular coagulation agents, the extracellular domain of coagulation-inducing protein tissue factor, truncated tissue factor (tTF), is the most widely used. Since the truncated protein exhibits...