FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

• Main Authors: Guoan Xiang (Author), Qi Li (Author), Di Lian (Author), Chengcheng Su (Author), Xin Li (Author), Shoulong Deng (Author), Lixin Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionImmunosuppression is the main cause of the high mortality rate in patients with sepsis. The decrease in the number and dysfunction of CD4+ T lymphocytes is crucial to the immunosuppressed state of sepsis, in turn affecting the development and prognosis of sepsis. Autophagy has been shown...