Modulation of Methotrexate Release from Nano-Hydrogels via Drug-Transition Metal Complexation

• Main Authors: Mahsa Taheri (Author), Samirasadat Abolmaali (Author), Mozhgan Abedanzadeh (Author), Samaneh Mohammadi (Author), Sanaz Javanmardi (Author), Alimohammad Tamaddon (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the extensive application of methotrexate (MTX) as a chemotherapeutic agent and an immune system suppressor, its therapeutic implementation has been limited due to its poor pharmacokinetics, saturable cellular transport, and insufficient response in some conditions. These limitations have re...