Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties

• Main Authors: Abdullah Elsayed (Author), Christian Pellegrino (Author), Louis Plüss (Author), Frederik Peissert (Author), Ramon Benz (Author), Franziska Ulrich (Author), Gudrun Thorhallsdottir (Author), Sheila Dakhel Plaza (Author), Alessandra Villa (Author), Jacqueline Mock (Author), Emanuele Puca (Author), Roberto De Luca (Author), Markus G. Manz (Author), Cornelia Halin (Author), Dario Neri (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTAntibody-based therapeutics represent an important class of biopharmaceuticals in cancer immunotherapy. CD3 bispecific T-cell engagers activate cytotoxic T-cells and have shown remarkable clinical outcomes against several hematological malignancies. The absence of a costimulatory signal thro...