A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment

• Main Authors: Hui Wang (Author), Monja Willershäuser (Author), Angelos Karlas (Author), Dimitris Gorpas (Author), Josefine Reber (Author), Vasilis Ntziachristos (Author), Stefanie Maurer (Author), Tobias Fromme (Author), Yongguo Li (Author), Martin Klingenspor (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Brown adipose tissue (BAT) dissipates nutritional energy as heat through uncoupling protein 1 (UCP1). The discovery of functional BAT in healthy adult humans has promoted the search for pharmacological interventions to recruit and activate brown fat as a treatment of obesity and diabetes...