Design and synthesis of novel hydroxamic acid derivatives based on quisinostat as promising antimalarial agents with improved safety

• Main Authors: Manjiong Wang (Author), Tongke Tang (Author), Zhenghui Huang (Author), Ruoxi Li (Author), Dazheng Ling (Author), Jin Zhu (Author), Lubin Jiang (Author), Jian Li (Author), Xiaokang Li (Author)
• Format: Book
• Published: Compuscript Ltd, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In our previous work, the clinical phase II HDAC inhibitor quisinostat was identified as a promising antimalarial agent through a drug repurposing strategy, but its safety was a matter of concern. Herein, further medicinal chemistry methods were used to identify new chemical entities with greater ef...