Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy

• Main Authors: Yacong Ji (Author), Chongyang Li (Author), Sicheng Wan (Author), Zhen Dong (Author), Chaolong Liu (Author), Leiyang Guo (Author), Shaomin Shi (Author), Mingxin Ci (Author), Minghao Xu (Author), Qian Li (Author), Huanrong Hu (Author), Hongjuan Cui (Author), Yaling Liu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from Stephania tetrandra S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear. Cellular proliferation assays, multi-omics analyses, and xenograft models were used to determine the effect...