Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies

• Main Authors: Ashraf K. El-Damasy (Author), Hyun Ji Kim (Author), Ahmed A. Al-Karmalawy (Author), Radwan Alnajjar (Author), Mohamed M. Khalifa (Author), Eun-Kyoung Bang (Author), Gyochang Keum (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic candidates. Herein, we have identified the first coumarin-based selective DDR1 inhibitors via repurposing of a recent series of ca...