Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance

• Main Authors: Gorka Ruiz de Garibay (Author), Francesca Mateo (Author), Agostina Stradella (Author), Rafael Valdés-Mas (Author), Luis Palomero (Author), Jordi Serra-Musach (Author), Diana A. Puente (Author), Ander Díaz-Navarro (Author), Gardenia Vargas-Parra (Author), Eva Tornero (Author), Idoia Morilla (Author), Lourdes Farré (Author), María Martinez-Iniesta (Author), Carmen Herranz (Author), Emmet McCormack (Author), August Vidal (Author), Anna Petit (Author), Teresa Soler (Author), Conxi Lázaro (Author), Xose S. Puente (Author), Alberto Villanueva (Author), Miguel Angel Pujana (Author)
• Format: Book
• Published: The Company of Biologists, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care. There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and genes that mediate resistance is incomplete. In this study, by modeling chemore...