Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages.

• Main Authors: Roberto Gimmelli (Author), Giuliana Papoff (Author), Fulvio Saccoccia (Author), Cristiana Lalli (Author), Sandra Gemma (Author), Giuseppe Campiani (Author), Giovina Ruberti (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide caused by Platyhelminthes of the genus Schistosoma. The treatment of schistosomiasis relies on the long-term application of a single safe drug, praziquantel (PZQ). Unfortunately, PZQ is very ef...