Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin

• Main Authors: Xiaoyu Chai (Author), Fulu Pan (Author), Qianqian Wang (Author), Xinyu Wang (Author), Xueyan Li (Author), Dongying Qi (Author), Zirong Yi (Author), Huan Liu (Author), Jing Zhang (Author), Yiming Zhang (Author), Yanli Pan (Author), Yang Liu (Author), Guopeng Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PurposeThe inhibition of thrombin has proven to be an efficacious therapeutic approach for managing cardiovascular disease (CVD), with widespread implementation in clinical settings. Oral ingestion of peptides and protein drugs is influenced by gastrointestinal digestive enzymes. We aimed to evaluat...