Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

• Main Authors: Gemma Navarro (Author), Marc Gómez-Autet (Author), Paula Morales (Author), Joan Biel Rebassa (Author), Claudia Llinas del Torrent (Author), Nadine Jagerovic (Author), Leonardo Pardo (Author), Rafael Franco (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding. Here, we show that a homobivalent ligand formed by equal chromenopyrazole moieties as phar...