Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron

• Main Authors: Alban Piotrowsky (Author), Markus Burkard (Author), Katharina Hammerschmidt (Author), Hannah K. Ruple (Author), Pia Nonnenmacher (Author), Monika Schumacher (Author), Christian Leischner (Author), Susanne Berchtold (Author), Luigi Marongiu (Author), Thomas A. Kufer (Author), Ulrich M. Lauer (Author), Olga Renner (Author), Sascha Venturelli (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several studies have demonstrated, both in vitro and in animal models, the anti-tumor efficacy of high-dose ascorbate treatment against a variety of tumor entities, including glioblastoma, the most common and aggressive primary malignant brain tumor. The aim of this study was to investigate the effe...