Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P‐gp Substrates in Patients With an Advanced Solid Tumor

Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P‐gp Substrates in Patients With an Advanced Solid Tumor

This phase I study (CO‐338‐044; NCT02740712), conducted in patients with advanced solid tumors, evaluated the effect of the poly(ADP‐ribose) polymerase (PARP) inhibitor rucaparib on the pharmacokinetics (PK) of caffeine 200 mg, warfarin 10 mg, omeprazole 40 mg, and midazolam 2 mg (cytochrome P450 (C...

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Main Authors: Jim J. Xiao (Author), Dorota Nowak (Author), Rodryg Ramlau (Author), Monika Tomaszewska‐Kiecana (Author), Piotr J. Wysocki (Author), Jeff Isaacson (Author), Jeri Beltman (Author), Eileen Nash (Author), Robert Kaczanowski (Author), Gerhard Arold (Author), Simon Watkins (Author)
Format: Book
Published: Wiley, 2019-01-01T00:00:00Z.
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