Anti-Inflammatory and Immunomodulatory Effects of the <i>Grifola frondosa</i> Natural Compound <i>o</i>-Orsellinaldehyde on LPS-Challenged Murine Primary Glial Cells. Roles of NF-κβ and MAPK

• Main Authors: Sarah Tomas-Hernandez (Author), Jordi Blanco (Author), Santiago Garcia-Vallvé (Author), Gerard Pujadas (Author), María José Ojeda-Montes (Author), Aleix Gimeno (Author), Lluís Arola (Author), Luisa Minghetti (Author), Raúl Beltrán-Debón (Author), Miquel Mulero (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an activated phenotype that promotes the release of pro-inflammatory mediators. This inflammatory mechanism, known as neuroinflammation, is essential in the defense against foreign invasion and in normal tissue repair;...