Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models

• Main Authors: Hongbo Cheng (Author), Yijiao Men (Author), Yaqing An (Author), Jiegang Yu (Author), Gengshen Zhang (Author), Jiaming Li (Author), Xiaoliang Wang (Author), Guozhu Sun (Author), Yang Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectivesThe disruption of blood-brain barrier (BBB) is associated with poor outcomes of TBI patients. Sphingosine-1-phosphate receptor 2 (S1pr2), a member of the G protein-coupled receptor family, is involved in endothelial activation and the regulation of vascular integrity. We hypothesized that...