Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo

• 主要な著者: Andrey V. Markov (著者), Anna A. Ilyina (著者), Oksana V. Salomatina (著者), Aleksandra V. Sen'kova (著者), Alina A. Okhina (著者), Artem D. Rogachev (著者), Nariman F. Salakhutdinov (著者), Marina A. Zenkova (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone methyl (<b>SM</b>), a cyano enone-bearing de...