Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo

• Main Authors: Andrey V. Markov (Author), Anna A. Ilyina (Author), Oksana V. Salomatina (Author), Aleksandra V. Sen'kova (Author), Alina A. Okhina (Author), Artem D. Rogachev (Author), Nariman F. Salakhutdinov (Author), Marina A. Zenkova (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone methyl (<b>SM</b>), a cyano enone-bearing de...