In Silico Analysis of Novel Titin Non-Synonymous Missense Variants Detected by Targeted Next-Generation Sequencing in a Cohort of Romanian Index Patients with Hypertrophic Cardiomyopathy

• Auteurs principaux: Miruna Mihaela MICHEU (Auteur), Nicoleta OPRESCU (Auteur), Nicoleta-Monic (Auteur)
• Format: Livre
• Publié: Sciendo, 2021-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background and aim: Most of detected variants in cardiogenetic panels are still classified as variants of unknown significance, requiring supplementary analyses for a definite classification. Performing further in-depth studies on such vast number of candidates is unfeasible. We sought to prioritise...