VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury

• Autors principals: Yan Li (Autor), Ke Li (Autor), Weihao Zhao (Autor), Haodong Wang (Autor), Xiaodong Xue (Autor), Xianghui Chen (Autor), Wantao Li (Autor), Peihao Xu (Autor), Kexin Wang (Autor), Pengfei Liu (Autor), Xuefei Tian (Autor), Rongguo Fu (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Background: As a novel non-apoptotic cell death, ferroptosis has been reported to play a crucial role in acute kidney injury (AKI), especially cisplatin-induced AKI. Valproic acid (VPA), an inhibitor of histone deacetylase (HDAC) 1 and 2, is used as an antiepileptic drug. Consistent with our data, a...