Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

• Main Authors: Jianpei Xu (Author), Yinzhe Sun (Author), Yang You (Author), Yuwen Zhang (Author), Dan Huang (Author), Songlei Zhou (Author), Yipu Liu (Author), Shiqiang Tong (Author), Fenfen Ma (Author), Qingxiang Song (Author), Chengxiang Dai (Author), Suke Li (Author), Jigang Lei (Author), Zhihua Wang (Author), Xiaoling Gao (Author), Jun Chen (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesenchymal stem cells (MSCs) experience substantial viability issues in the stroke infarct region, limiting their therapeutic efficacy and clinical translation. High levels of deadly reactive oxygen radicals (ROS) and proinflammatory cytokines (PC) in the infarct milieu kill transplanted MSCs, wher...