Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [18F]PSS232 in the Rat Brain

• Main Authors: Adrienne Müller Herde (Author), Silvan D. Boss (Author), Yingfang He (Author), Roger Schibli (Author), Linjing Mu (Author), Simon M. Ametamey (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Several studies showed that [11C]ABP688 binding is altered following drug-induced perturbation of glutamate levels in brains of humans, non-human primates and rats. We evaluated whether the fluorinated derivative [18F]PSS232 can be used to assess metabotropic glutamate receptor 5 (mGluR5) availabili...