Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [18F]PSS232 in the Rat Brain

• Váldodahkkit: Adrienne Müller Herde (Dahkki), Silvan D. Boss (Dahkki), Yingfang He (Dahkki), Roger Schibli (Dahkki), Linjing Mu (Dahkki), Simon M. Ametamey (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2018-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Several studies showed that [11C]ABP688 binding is altered following drug-induced perturbation of glutamate levels in brains of humans, non-human primates and rats. We evaluated whether the fluorinated derivative [18F]PSS232 can be used to assess metabotropic glutamate receptor 5 (mGluR5) availabili...