Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Four isobutyric acids (two nitro and two acetamido derivatives) were prepared in two steps and characterized using spectral analysis. The mRNA concentrations of PPARγ and GLUT-4 (two proteins documented as key diabetes targets) were increased by 3T3-L1 adipocytes treated with compounds <b>1<...

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Main Authors: Blanca Colin-Lozano (Author), Héctor Torres-Gomez (Author), Sergio Hidalgo-Figueroa (Author), Fabiola Chávez-Silva (Author), Samuel Estrada-Soto (Author), Julio Cesar Almanza-Pérez (Author), Gabriel Navarrete-Vazquez (Author)
Format: Book
Published: MDPI AG, 2022-01-01T00:00:00Z.
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3rd Floor Main Library

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