Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

• Main Authors: Heidi Gytz Olesen (Author), Iliana Michailidou (Author), Wioleta M. Zelek (Author), Jeroen Vreijling (Author), Patrick Ruizendaal (Author), Ferry de Klein (Author), J. Arnoud Marquart (Author), Thomas B. Kuipers (Author), Hailiang Mei (Author), Yuchun Zhang (Author), Muhammad Ahasan (Author), Krista K. Johnson (Author), Yi Wang (Author), B. Paul Morgan (Author), Marcus van Dijk (Author), Kees Fluiter (Author), Gregers Rom Andersen (Author), Frank Baas (Author)
• Format: Book
• Published: Karger Publishers, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous system. Animals deficient in the complement com...