Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1

• Main Authors: Dan Liang (Author), Zhiyang Li (Author), Zhaowei Feng (Author), Zhiping Yuan (Author), Yunli Dai (Author), Xin Wu (Author), Fan Zhang (Author), Yuanyuan Wang (Author), Yuxia Zhou (Author), Lingling Liu (Author), Mingjun Shi (Author), Ying Xiao (Author), Bing Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic kidney disease is a major cause of chronic kidney condition and the most common complication of diabetes. The cellular senescence participates in the process of diabetic kidney disease, but the specific mechanism is not yet clear. Cell cycle-related protein E2F transcription factor 1 (E2F1)...